Manchester City midfielder Fernandinho could be fit to start, having played as a substitute against Spurs in midweek on his return from a muscular problem.
Oleksandr Zinchenko, who has been out with a hamstring injury, will be assessed.
Tottenham look likely to be without Moussa Sissoko, who was substituted on Wednesday because of a groin problem.
Eric Dier will return to training on Friday after a hip injury and could be involved this weekend.
Serge Aurier, Harry Winks and Harry Kane remain out.
MOTD COMMENTATOR’S NOTES
However many changes are made, most of those involved will have had plenty taken out of them – but there can be no let up in intensity with the title and a top-four finish to fight for.
City won’t let disappointment affect them. They still won the game on Wednesday, and if anything it will spur (sorry) them on even more to go for the treble. It remains in their hands.
Spurs might as well have another good go. They know they can’t contain City all game, and that they can hurt them on the counter attack.
I’ll tip it to be half as good as Wednesday, which will still be very good indeed.
VIEW FROM THE DUGOUT
Manchester City manager Pep Guardiola: “I think the game against Spurs will be just as intense as the other day.
“If you believe it doesn’t hurt, you’re wrong, but we have to live with that. We lost [the tie] but I was so proud. The performance we did was incredible.
“We are going to attack – it won’t be easy because they are an incredible top team, but we will try.
“The title race for us is Tottenham at 12.30pm. What Liverpool do at Cardiff I cannot control.”
Tottenham Hotspur manager Mauricio Pochettino: “We didn’t sleep too much [on Wednesday night] but the happiness allows you to feel strong and with energy, and of course now we’re thinking about the game on Saturday.
“We don’t have time to enjoy and we need to forget the Champions League now and try to be ready for Saturday because it’s going to be a battle.
“It is our responsibility all together to try to make sure we are going to be there on Saturday with the capacity to fight and challenge them again.”
Surely Manchester City won’t be as open in this game as they were on Wednesday night – they cannot afford to invite any more chaos this time.
I would expect Fernandinho to start on Saturday and, if he is patrolling those deep midfield areas, I think City will control the game this time far better than they did in midweek.
- Manchester City are vying to equal their club record of four consecutive top-flight wins against Spurs.
- Tottenham have lost seven of their past nine visits to the Etihad Stadium in all competitions, conceding 27 goals. Their only victory in that period came in the league in February 2016.
- City’s streak of nine successive Premier League wins equals the best run by any club this season. Liverpool won nine in a row during November and December.
- Pep Guardiola’s side have won 24 of their past 26 league and cup matches, including the penalty shootout victory in the Carabao Cup final.
- They need two more goals in all competitions to equal the record of 156 by a top-flight side in a season, set by City themselves in 2013-14.
- Manchester City have earned an unsurpassed 19 points this season in games against established top-six rivals. Liverpool have accrued as many points but played one game more.
- City have won eight of their past nine home league matches against the rest of the current top six, including all four this season.
- Sergio Aguero has gone six league appearances without a goal against Tottenham. He scored 10 in his first seven matches in this fixture.
- Aguero needs one goal to become just the second player to score 20 times in the Premier League in five successive seasons, emulating Thierry Henry.
- Spurs are on a run of four Premier League away defeats in a row, conceding two goals each time. They haven’t fared worse since a six-match losing streak on the road between March and May 2004.
- They have lost seven of their past eight away fixtures in all competitions, with the exception being a 1-0 victory at Borussia Dortmund in the Champions League on 5 March.
- Nonetheless, Spurs are the division’s leading scorers in away matches, with 33 goals.
- They are one point shy of matching the club’s best Premier League away tally in a season: 34 in 2012-13, 2015-16 and 2017-18.
- Tottenham have the second poorest record in league games between the established top-six sides this season, with seven points (W2, D1, L6). Manchester United have six points.
- Mauricio Pochettino’s side have won all five of their league games without Harry Kane this season.